Emulsions are used in dermal treatments due to their good skin penetration and adherence to surfaces. They remain in the surface of the skin without drying out. A stabilizing agent is most usually employed to improve the stability of the emulsion. These are irritants to the skin, especially in conditions such as Contact Dermatitis, Psoriasis or Eczema.
A Pickering emulsion is an emulsion that is stabilized by solid particles adsorbed onto the interface between the two phases. In addition to improvements in the toxicology profile, these nanoparticle pickering emulsion control drug release from the emulsion.
Depending on the deposition of particles, different drug release profiles are achieved. Supersaturation conditions are achieved and sustained for a longer period of time within the nanoparticle coated droplet.
Silica nanoparticles from the Pickering emulsions can penetrate up to 5 um in the skin. In addition to benefits from normal Silica pickering soutions, Drug loaded porous silica particles can continue drug delivery system once embedded within the Stratum Corneum.
Nanologica has developed several candidate dermal delivery systems that are transferable to applications in the cosmetic sector. Our cosmetic delivery vehicles based on nanoporous silica not only offer sustained release of the active ingredient and additional stability at a low cost, but also a practical solution to formulation and solubility issues of active cosmetic ingredients. Our cosmetic porous silica powders are commercially available on their own as well as together with active cosmetic products such as vitamin A, B, C and derivatives.
Adapting controlled release technologies to the delivery of DNA has the potential to overcome extracellular barriers that limit gene therapy. Controlled release systems can enhance gene delivery and increase the extent and duration of transgene expression relative to more traditional delivery methods. These systems typically deliver vectors locally, which can avoid distribution to distant tissues, decrease toxicity to nontarget cells, and reduce the immune response to the vector. Delivery vehicles for controlled release are fabricated from natural and synthetic polymers, which function either by releasing the vector into the local tissue environment or by maintaining the vector at the polymer surface. Vector release or binding is regulated by the effective affinity of the vector for the polymer, which depends upon the strength of molecular interactions. These interactions occur through nonspecific binding based on vector and polymer composition or through the incorporation of complementary binding sites. This review examines the delivery of nonviral and viral vectors from natural and synthetic polymers and presents opportunities for continuing developments to increase their applicability.
Nanotechnology is expected to have an impact on all industries including semiconductors, manufacturing, and biotechnology. Tools that provide the capability to characterize and manipulate materials at the nanoscale level further elucidate nanoscale phenomena and equip researchers and developers with the ability to fabricate novel materials and structures. One of the most promising societal impacts of nanotechnology is in the area of nanomedicine. Personalized health care, rational drug design, and targeted drug delivery system are some of the benefits of a nanomedicine-based approach to therapy. This review will focus on the development of nanoscale drug delivery system mechanisms. Nanostructured drug carriers allow for the delivery of not only small-molecule drugs but also the delivery of nucleic acids and proteins. Delivery of these molecules to specific areas within the body can be achieved, which will reduce systemic side effects and allow for more efficient use of the drug.
drug delivery system and related pharmaceutical development in the context of nanomedicine should be viewed as science and technology of nanometer scale complex systems (101000 nm), consisting of at least two components, one of which is a pharmaceutically active ingredient, although nanoparticle formulations of the drug itself are also possible. The whole system leads to a special function related to treating, preventing
or diagnosing diseases sometimes called smart-drugs or the ragnostics.
A Pickering emulsion is an emulsion that is stabilized by solid particles adsorbed onto the interface between the two phases. In addition to improvements in the toxicology profile, these nanoparticle pickering emulsion control drug release from the emulsion.
Depending on the deposition of particles, different drug release profiles are achieved. Supersaturation conditions are achieved and sustained for a longer period of time within the nanoparticle coated droplet.
Silica nanoparticles from the Pickering emulsions can penetrate up to 5 um in the skin. In addition to benefits from normal Silica pickering soutions, Drug loaded porous silica particles can continue drug delivery system once embedded within the Stratum Corneum.
Nanologica has developed several candidate dermal delivery systems that are transferable to applications in the cosmetic sector. Our cosmetic delivery vehicles based on nanoporous silica not only offer sustained release of the active ingredient and additional stability at a low cost, but also a practical solution to formulation and solubility issues of active cosmetic ingredients. Our cosmetic porous silica powders are commercially available on their own as well as together with active cosmetic products such as vitamin A, B, C and derivatives.
Adapting controlled release technologies to the delivery of DNA has the potential to overcome extracellular barriers that limit gene therapy. Controlled release systems can enhance gene delivery and increase the extent and duration of transgene expression relative to more traditional delivery methods. These systems typically deliver vectors locally, which can avoid distribution to distant tissues, decrease toxicity to nontarget cells, and reduce the immune response to the vector. Delivery vehicles for controlled release are fabricated from natural and synthetic polymers, which function either by releasing the vector into the local tissue environment or by maintaining the vector at the polymer surface. Vector release or binding is regulated by the effective affinity of the vector for the polymer, which depends upon the strength of molecular interactions. These interactions occur through nonspecific binding based on vector and polymer composition or through the incorporation of complementary binding sites. This review examines the delivery of nonviral and viral vectors from natural and synthetic polymers and presents opportunities for continuing developments to increase their applicability.
Nanotechnology is expected to have an impact on all industries including semiconductors, manufacturing, and biotechnology. Tools that provide the capability to characterize and manipulate materials at the nanoscale level further elucidate nanoscale phenomena and equip researchers and developers with the ability to fabricate novel materials and structures. One of the most promising societal impacts of nanotechnology is in the area of nanomedicine. Personalized health care, rational drug design, and targeted drug delivery system are some of the benefits of a nanomedicine-based approach to therapy. This review will focus on the development of nanoscale drug delivery system mechanisms. Nanostructured drug carriers allow for the delivery of not only small-molecule drugs but also the delivery of nucleic acids and proteins. Delivery of these molecules to specific areas within the body can be achieved, which will reduce systemic side effects and allow for more efficient use of the drug.
drug delivery system and related pharmaceutical development in the context of nanomedicine should be viewed as science and technology of nanometer scale complex systems (101000 nm), consisting of at least two components, one of which is a pharmaceutically active ingredient, although nanoparticle formulations of the drug itself are also possible. The whole system leads to a special function related to treating, preventing
or diagnosing diseases sometimes called smart-drugs or the ragnostics.