NANOTECH INNOVATIONS

There is a general perception that nanotechnologies will have a significant impact on developing 'green' and 'clean' technologies with considerable environmental benefits. The best examples are the use of nanotechnology in areas ranging from water treatment to energy breakthroughs and hydrogen applications. As a matter of fact, renewable energy applications probably are the areas where nanotechnology will make its first large-scale commercial breakthroughs.

Researchers agree that the safest possible future for advancing nanotechnology in a sustainable world can be reached by using green chemistry. Green chemistry means designing chemical products and processes in a way that reduces or eliminates hazardous substances from the beginning to end of a chemical product’s life cycle. The practice began in the United States with the passage of the Pollution Prevention Act of 1990, which established a national policy to prevent or reduce pollution at its source whenever feasible. Reducing pollution at the source, according to the act, "is fundamentally different and more desirable" than managing waste and controlling pollution. Since then, the EPA Green Chemistry Program has built collaborations with academia, industry, other government agencies, nongovernmental organizations and international partners to promote pollution prevention through green chemistry.

As the report "Green Nanotechnology: It's easier than you think" (pdf) states: "Green nanotechnology offers the opportunity to head off adverse effects before they occur. Green nanotechnology can proactively influence the design of nanomaterials and products by eliminating or minimizing pollution from the production of the nanomaterials, taking a life cycle approach to nanoproducts to estimate and mitigate where environmental impacts might occur in the product chain, designing toxicity out of nanomaterials and using nanomaterials to treat or remediate existing environmental problems. Green nanotechnology does not arise de novo; rather, it builds on the principles of green chemistry and green engineering and focuses them through a new lens on the unique and often counter intuitive effects that occur in nanoscale materials.

Apart from the obvious areas of using nanomaterials in the areas of solar cells, biofuels and fuel cells, green nanotechnology applications might involve a clean production process, such as synthesizing nanoparticles with sunlight or the recycling of industrial waste products into nanomaterials, such as turning diesel soot into carbon nanotubes.

It has long been recognized that the physical form of materials can mediate their toxicity—the health impacts of asbestiform materials, industrial aerosols, and ambient particulate matter are prime examples. Yet over the past 20 years, toxicology research has suggested complex and previously unrecognized associations between material physicochemistry at the nanoscale and biological interactions. With the rapid rise of the field of nanotechnology and the design and production of increasingly complex nanoscale materials, it has become ever more important to understand how the physical form and chemical composition of these materials interact synergistically to determine toxicity. 

As a result, a new field of research has emerged—nanotoxicology. Research within this field is highlighting the importance of material physicochemical properties in how dose is understood, how materials are characterized in a manner that enables quantitative data interpretation and comparison, and how materials move within, interact with, and are transformed by biological systems. Yet many of the substances that are the focus of current nanotoxicology studies are relatively simple materials that are at the vanguard of a new era of complex materials. 

Over the next 50 years, there will be a need to understand the toxicology of increasingly sophisticated materials that exhibit novel, dynamic and multifaceted functionality. If the toxicology community is to meet the challenge of ensuring the safe use of this new generation of substances, it will need to move beyond “nano” toxicology and toward a new toxicology of sophisticated materials. Here, we present a brief overview of the current state of the science on the toxicology of nanoscale materials and focus on three emerging toxicology-based challenges presented by sophisticated materials that will become increasingly important over the next 50 years: identifying relevant materials for study, physicochemical characterization, and biointeractions.