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As the names suggest, nanoscience and nanotechnology constitute the study and the application of objects with at least one of the dimensions smaller than 100 nanometres. A nanometre is a billionth of a metre or 1/80,000 the diameter of a human hair. Figure 1 gives an idea of its scale. At this level, objects are so small that they can no longer be assumed to be continuous media but rather to consist of discrete elements made up of atoms and molecules; that is, nanoscale objects and their behaviour/performance can best be understood from the molecular viewpoint.

Since early civilisation, mankind learnt that metals can be melted and recast into desired mould-determined shapes. At the dawn of this millennium, Anat Hatzor and Paul S Weiss from Pennsylvania State University developed the smallest-ever mould on the scale of a few molecules. The mould consists of parallel gold nanostructures on a silicate substrate developed using standard electron-beam lithography. By applying layers of organic molecules, the widths of the gold nanostructures widen, thereby narrowing the gaps between the strips of gold. These gaps work as the mould for casting thin wires 15-70nm wide. With a spacing of 10-40nm, these gaps allow numerous nanowires to be moulded at one time.

Most nanotubes, if not all, are made from carbon. Erman Bengu and Laurence D Marks recently developed nanotubes from two elements - boron and nitrogen. These boron nitride nanotubes (BNNTs) have higher tolerance to heat and are less likely to oxidise. To produce BNNT, they sprayed boron and energetic nitrogen atoms onto a heated tungsten surface in a vacuum so that the nanotubes grew as a kind of hair. The BNNT, according to Marks, has the potential for use in reducing friction on bearings in heavy machinery.

This report concentrates on innovations in oral solid dose delivery systems (OSDDS) with an emphasis on the links between start up companies and academic collaborations. It deals with the impact of the difficult economic climate with the restriction on funding and opportunities for partnering projects.

Developments are assessed in relation to understanding the dynamics of the market. For instance the report discusses the loss of patent protection for blockbuster drugs peaking between 2007-2012, loss of patent protection for the first-generation of OSDDS in the last few years, the dearth of NCEs coming through the pipeline and puts new developments in the context of a market that is seeing a decline in its value in some therapeutic areas. It identifies the drivers for new OSDDS and the issues surrounding them.

A key theme is the transition of peptides and proteins from intravenous to oral delivery. The report looks at the competitive landscape, making reference to sales and market dynamics. A recurring theme is the reformulation of old generic drugs to get over inadequacies in the original drug for instance: low solubility, bioavailability, short duration of action, high side effect potential, poor stability, poor absorption following oral administration, bitter or unpleasant taste, narrow GI absorption window and inter- and intra-patient variability in absorption.

With a growing geriatric population and with people living longer much of the emphasis is on development of OSDDS drugs to more effectively treat diseases of an aging population such as Alzheimers disease, Parkinsons disease, type 2 diabetes and obesity, osteoporosis, cancer and rheumatoid arthritis, etc. Often these treatments have side effects, problems with dosing and short duration of action or have to be administered by injection which reduces their acceptability.

Key features of this report

Analysis of innovative platform technologies, companies and product development pipelines involved in transitioning injectable to oral drug delivery.
Review of companies and technologies developing oral formulations of peptides and small proteins, highlighting stage of development, indications and competitive nature of the area.
Providing an understanding of the specific problems involved in transitioning intravenous peptides to oral delivery and the mechanisms of crossing the GI mucosa, together with a review of approaches utilized.
Analysis of sales data, growth rates, market share, generic entrants, new products for therapeutic areas in which the new products using the new technologies will compete.
Assessment of market potential of the new osdds products in relation to the current market and competitors.

Scope of this report

Get a comprehensive understanding of the range of new innovative osdds technologies and how they can overcome problems with the original active ingredient.
Identify potential novel technologies which might allow you to overcome a problem with your own drug portfolio or which would allow you to extend your products franchise in the market place.

Allow you to identify potential licensing opportunities or collaborations with innovative technology companies and assess the potential with respect to recent products commercialized.
Allows you to identify which companies and which therapeutic areas are successful in gaining backing for their technologies and those that are not.

Identify the time scales, hurdles and progress in developing new innovative technologies such as nanotechnologies/nanomedicines, oral peptides and proteins, new prodrugs and assess market factors affecting the developments and their success/failure.

Key Market Issues

As the population ages and those elderly people live longer there is a greater need for better drugs which treat chronic conditions associated with aging such as Alzheimers disease, Parkinsons disease, osteoporosis, rheumatoid arthritis, osteoarthritis, type 2 diabetes and obesity,cancer, hypertension and heart disease.

The specific challenges in providing for mentally ill patients in which compliance is a problem is driving the demand for formulations which get over problems with swallowing difficulties, frequent dosing, variability in oral absorption or bioavailability,unacceptable side effect potential .

The low numbers of new chemical entities approved annually (around 30 compared to 40-50 three decades ago), the record number of blockbuster drugs becoming generic up to 2012 and the first-generation delayed-release products losing patent protection is depressing the sales value in certain billion dollar therapy markets.

Key findings from this report

The development of oral peptide hormones is a highly competitive area with many companies developing oral versions of the same peptide and these products will have to compete with new developments in inhaled peptides and very long-duration transdermal or sc depot products which are several years ahead of oral formulations.

The failure of Exubera (inhaled insulin) has had a knock on effect on the development of new oral insulins with investors seeing oral insulins as being more risk prone and in addition the issues encountered with some oral insulins has meant that some companies are no longer considering this area a key focus.

Many dds companies have switched their development focus to new oral GLP-1 analogs for the treatment of type 2 diabetes and obesity in the light of Byettas success but these oral products are several years behind the development of new long-acting transdermal, injectable and inhaled GLP-1 analogs .

Generic nasal calcitonin products have depressed the value of second-generation nasal preparations which are still patent protected thus this does not bode well for prices achievable for oral salcatonin products which are nearing the market as they have to offer better therapeutic outcomes in order to achieve higher prices and ultimately market share.

Key questions answered

What oral peptide products have the greatest growth potential and how far along the development path have they reached?
What are the strategies employed by brand leaders to protect their franchise in the $10 billion US antiepileptic market in the face of recent generic competition?
How has the failure of Exubera (inhaled insulin) affected the oral insulin developments and oral peptides in general?
What are the main diseases and how advanced are the oral peptide and protein formulations?
How successful is prodrug technology in terms of drug development and what are the latest developments?
What innovative companies and platform technologies are attracting investment and collaboration agreements?


There is hardly any doubt that nanotechnology is very beneficial to man. With all the applications this new frontier of knowledge has seen from the human body to industries and chemicals, thus far, nanotechnology has lived up to its name in enhancing the wealth of knowledge possessed by man.

Despite this gains however, nanotechnology research continues on high gear to discover more truths that will help man in so many ways. Today, nanotechnology research is not only limited to the laboratories of scientific bodies, personnel under the employ of big companies that benefit from nanotechnology are also doing their own nanotechnology researches.

Frontiers of Nanotechnology Application

The following are the various areas where some of the most prominent nanotechnology research are being undertaken:

The field of heavy equipment and industries are some of the busiest areas of nanotechnology research. With the projected benefits nanotechnology promises these industries, there is no wonder why they should busy themselves with furthering the impact of nanotechnology. The main benefit comes in the form of creating machineries that are light yet very durable. When equipments are made lighter, they do not cause much strain on the engine, thus it maximizes the consumption of fuel.

The aerospace and aircraft production industries are also bound to benefit from continuing nanotechnology research. This is because with nanotech, aircraft and rocket parts are made lighter, thus minimizing fuel consumption. As a result, companies that are in the air travel business are also benefited from lower fuel consumption from aircrafts that are lighter and speedier.

In the field of optical technology, nanotechnology research is used to develop lenses and glasses that are scratch-resistant and tough. It also results to the creation of lenses that do not cause interference with one’s vision, thus giving the wearer clarity of sight sans any inconvenience.

In the field of cosmetics, one important research on nanotechnology leads to the development of sunscreen based on nano particles. As a result, sunscreens are better when it comes to providing protection from the sun compared to the traditional UV protection systems that is the standard today in most sunscreen products. With nanotechnology-based sunscreens, the cosmetic is able to penetrate deeper into the skin layers to cause the cells to react against getting burned by the sun. This is considered to be far better than simply superficial sun blockage, which is common in conventional sunscreen cosmetics.

In health, nanotechnology research is also key to advancing tissue engineering. This is very important when there is a need to repair damaged tissues, especially those affected by severe diseases. Moreover, nanotechnology is also one of the most promising applications that scientists are employing in the fight against the human immunodeficiency virus (HIV). In this, the process aims at killing affected cells to prevent their replication and thus stop the spread of the disease. Moreover, because it is atomic in nature, nanotechnology is far better than taking medications because unlike the latter, it does not affect otherwise healthy tissues, specifically attacking only the affected ones.







There are many applications of nanotubes that have the potential to change the face of humankind. Nanotechnology could change everything and the purpose of nanotubes is change the way we treat diseases to how we purchase our everyday essentials like food.

While most applications for nanotubes are still quite futuristic, the progress in this relatively young science has been astonishing. The 1990s and the early part of the 21st century has proven to be a continuous developmental promise for the applications of carbon nanotubes.

Nanotubes are a round connection of atoms that create one of three distinctive patterns, capped at the ends by fullerene molecules. These tubes can be manipulated with care to conduct electricity and to withstand very great stresses.

The nanotubes are stronger than steel and can be directed to take on specific human cell or be used to create special coatings for the quantum wires that can be used for a host of potential applications of nanotechnology.

While the idea of materialization is still rather far from our current reality, but this could essentially become another application for nanotubes, nanotechnology, and the high tech communications that would be necessary for such an event. The idea is that nanotechnology could potentially dispense with the need for a monetary system.

With materialization, high tech machines would allow people to simply push a button for their daily needs. The molecular structure of the item would be completed by the machines that are in each home. With this sort of immediate response system, there would be no need for money in our society for daily items.

The idea might seem far fetched and even in the realm of science fiction, but the potential is there as one of the many applications of nanotubes.

Nanotubes are very good at conducting communicative impulses, whether in the body or through technological devices. With the creation of special coatings for the nanotubes, the science may very well give sight to the blind, sound to the hearing impaired, and motion to the paralyzed.

Medically speaking we could soon find a new field of specialty known as nanosurgery. In these procedures, cancer cells or other diseased cells could be eradicated from the body and then replaced by engineered nanotubes that are ready to redevelop the diseased cells with healthy impulses.

It is speculated that the application of nanotubes in medical procedures are likely to completely change the way illness and injury are handled.

Ecologically speaking, nanotubes can change the way we perform ecological research. With the nanotubes, we can create very tiny chips that can record and transmit information that is vital to understanding the way the creatures within the environment are being affected by the changing world.

Through these observations, we can then determine the best way to coexist with the natural world while understanding the impact on ecology we have all the way down to insects and fauna.

The purpose of nanotubes is to potentially help with understanding the realm of space. Scientists can create computers that are crafted from particles and wires that are as small as human cells.

This would mean that we would be able to send these ultra tiny communication devices farther into space.

Since the nanotube is about 100 times stronger than steel, the chances of it making back to Earth despite the atmospheric conditions are probable. Scientists could then download or track the information from these tiny computer devices in order to know what lays beyond the limits of human exploration of space.

As the science of nanotechnology progresses the applications for nanotechnology will grow and expand. Many nano scientists believe that there will be no limits to the power of progress that nanotubes will introduce to the world over the next fifty years.

Because this science is so young, it is almost impossible to predict just how much something that measures one tenth the width of a human hair will be able to change our world and improve our living conditions.

Everything from ultra smart nano robots to changes in the health care options patients have, and even the potential to engineer our children to be smarter and faster people could be the result of finding new applications for nanotubes.

Nanotechnology focuses on manipulating atoms individually and placing them in a pattern to produce a desired structure. It is diverse field that has various branches colloidal science, applied physics, material science, supramolecular chemistry, device physics and even electrical and mechanical engineering. Nanotechnology uses two main approaches, known as to-up and bottom-down approaches.

In the "top-down" approach, the nano-objects are assembled from larger molecular objects without atomic-level control. In the "bottom-up" approach, materials and devices are built from molecular components which constructs chemically by the principles of molecular recognition. Instances of nanotechnology in recent use are the production of polymers based on molecular structure, and the design of computer chip layouts based on surface science. When the nanotechnology is implemented in image analysis software, some computers are able to study a consumer's body language and, with exact programming can precisely understand a person's position, impatience and diverse facial expressions like frowning, smiling or scowling.

Human skin has the ability of broadcasting the electric signals which can be used as a method of transmission, researchers have already been able to develop computers that are designed with nano sensors that have the strange ability to 'see' and 'hear' the people using them in reality. Nanotechnology would facilitate manufacturing of new generation of computer components with massive storage capacity. In the field of computer science, there is something called as Moore's Law which states that, in layman's terms, the processing abilities of the basic computer chip have been increasing exponentially to a greater heights every eighteen months since their inception.

The evolution of the computers clearly shows us that mechanical computing tradition was not completely abandoned. In 1990, University of Minnesota engineers fabricated an entire family of micromechanical digital logic devices, including electrostatically-actuated linear sliding micron mechanical logic elements limited to a one-dimensional track, suitable for low speed radiation-hard digital works in an environment hostile to the electronic devices to operate. Perhaps the best-characterized mechanical nanocomputer is Drexler's rod logic design which is though not yet built. In this model, one sliding rod with a knob interconnects at first a second knobbed sliding rod at right angles. Based upon the location of the first rod, the second may be able to move, or unable to move. This straightforward blocking contact serves as the basis for logical operations.

There has been a lot of research work going on this for the betterment of the mankind. In a press meet to Journal of Applied Sciences Hewlett-Packard said that their scientists have invented an alternative to eventually replace the transistors in computers. This was demonstrated by their Quantum Science Research group. They have invented a "crossbar latch," which supplies the signal restoration and inversion necessary for general computing without the need for transistors.

Nanotechnology has worked its way into the field of processing. Nanoparticles are defined as units of substance that maintain that substance's properties that exist between 100 and 2500 nanometers. Particles smaller than this are considered "ultrafine," while particles that lose the original substance's properties would simply be considered another material altogether. While seeds of nanoparticle research date back a millennia, most of the great advancements have taken place within the last century. Scientists are especially intrigued by nanoparticles as a "missing link" between viewable materials and their atomic or even subatomic structures. The output of this research has made its way into the processing industry, with some of the benefits being felt immediately.

For example, in the medical industry, the processing of nanoparticles is allowing for the mass production of multiple drugs that once was deemed impossible or too difficult or time consuming to be deemed of any value. Breaking down materials to the nanoparticle level increases the overall surface area of a material for a given size (compared to if the material were intact) which makes it more soluble or dissolvable in water and other liquids. This allows manufactures to fit more substances into a given product or create new compounds at the nanoparticle level. This could be done before modern day nanoparticle research, but was a painstaking process that had to be done individually for each product. By increasing the efficiency for producing a given product, costs are made more manageable and we see the production of certain materials that simply was not feasible for previous manufacturers.


Nanoparticle processing is not without its challenges. The obvious issues lie with managing and developing materials that are, for the most part, invisible to the naked eye. But, for producers, one of the greatest challenges is posed with mixing nanoparticles for the product. Certain types of mixers can lead to contamination or an uneven mix. Ensuring a that the particles are mixed evenly is key for any type of manufactured product, but with nanoparticles, simply viewing the mixture after the fact will likely prove to be insufficient, so ensuring a proper mixture from the get go is key.

With this in mind, planetary mixers have proven to be very effective for the mixture of nanoparticles for industries that require their processing. Often used for creating pastes, planetary mixers have proven effective for mixing nanoparticles evenly across a variety of process sizes (up to 750 gallons in practice). Planetary mixers typically come in two varieties, single arm and double arm. These arms extend through the containment unit with smaller perpendicular arms extending out from the main arm. The overall effect is that virtually the entire product is subject to mixing at all times within the basin.

Nanotechnology is here and will only continue to grow in use and popularity in the coming decade. Where once the challenges existed in synthesizing these materials, the issues now lie more in how to work with materials that are already in existence. Having the proper equipment to deal with the challenges posed by working with such tiny materials will be vital in taking advantages of the developments in this field.

How and why tungsten nanospheres work:

To start, nano particles (spheres) are hard to imagine. So small, that they can interact with engine lubricant and other matter on a molecular level.

This interaction allows them to become one with both the metal surfaces and the lubricant they are exposed to.

The tungsten component is chemically inert, stable and unaffected by temperatures encountered in application as a lubricant. Tungsten nanospheres will not alter the carrier, exposure to them alters the way the metal of the friction surfaces interact with the lubricant .

Once the metals are exposed to the tungsten component in the carrier fluid, metal to metal friction is dramatically reduced, if not eliminated.

This will increase engine efficiency (gas mileage).

The end result is a dramatic reduction in wear, the friction that causes wear, heat, and power losses. This will also increase gas mileage.

Benefits:

Lower friction (improved lubricity, lower energy costs. )

Measurably better gas mileage , reduce wear, increase efficiency and

increased horsepower.

Lower operating temperatures (as less energy is converted into heat)

Increase in Oil / lubricant life and longer changeovers

High Load bearing property means Reduction in wear of mating parts

Offers increased corrosion resistance

Does not clog oil or fuel filters as .5 micron particles easily pass thru filter.

Characteristics :

Nanoparticles are defined as any particle with a size less then 100 nanometer (0.1 micronmeter).

When materials are made into nanoparticles, their reactivity increases. Nanoparticles have a very high surface area to volume ratio, due to this, a higher percentage of atoms (in nanoparticles) can interact with other matter. Therefore, the surface area (measured in square meters per gram) is the most important unit of measure for nanoparticles.The higher the surface area,the higher the lubricity.

Tungsten nanospheres as applied to engine lubrication:

Tungsten nanoparticles are one of the most expensive and highly developed lubricant additives available today.

Nano technology, as applied to lubricant additives, suspends the tungsten spheres in the circulating lubricant. This allows the tungsten component to be applied to all metal bearing surfaces, as well as cylinder walls, pistons and piston rings.

The important characteristic of nanoparticles, is that they bond to the metal friction surfaces. Essentially "plating" them, preventing metal – to metal contact. Tungsten is one of the most wear – resistant substances known to man.

Tungsten is temperature resistant far beyond what is encountered in any automotive application.

Nanotechnology is growing by leaps and bounds, especially in the fields of medicine, electronics, space and even the automotive industry, just to name a few. There are many different applications for nanotech. One of the fields that hits close to home is in the field of medicine.

Nanotechnology is simply the rearranging of atoms to make other things, or to improve what is already available. For and example, organic nanotech is being researched and used to infuse cancer medications with atoms to attach cancer cells, while leaving healthy cells intact. Imagine those people with cancer, going in for just one or two treatments, and having their cancer cells destroyed, without harming their immune system. This way, those who are on chemotherapy now and are suffering from other problems, anemia, their hair falling out etc, and staying healthy but cured of the cancer they may have.

This is just the start, nanotech can help in many other ways, including correcting genetic defects, or healing ailments. For another example, let’s look at people who have eye problems, especially nerve damage causing blindness. With nanotechnology, a bridge can be built across the gap between damaged nerves and the eye, that can get new nerves to grow and bridge this gap, allowing those that are blind to see again.

Nanotechnology is also growing in many travel areas. Building materials will be lighter, and stronger, making planes, boats and even space ships easier to build, longer lasting, and able to consume much less fuel. Road construction will also be cheaper, and roads and bridges lasting much longer than ever before. This will cut transportation costs across the board, make traveling easier and much safer. This will also make the building of power plants safer as well, and soon we won’t have the problems that we are faced with today, such as the explosion and melt down of the nuclear power plant in Japan after the recent earthquakes. Building will be stronger in general, and able to withstand natural disasters much better. This include fires and floods as well, whether natural or man made.

Nanotechnology has applications for law enforcement and the military as well. Bullet proof vests will be lighter, yet better able to absorb or deflect bullets. The same holds true for military and law enforcement vehicles, Humvees, tanks and other vehicles stronger, and better able to withstand attacks. Also, with new advances in nanotech, soldiers will be able to heal their injuries faster, be stronger and more agile.

For the automotive industry, with the use of nanotechnology, metals will be stronger, yet lighter. Fuel will be more effective, oils and other lubricants able to get into even the smallest parts. This will make vehicles last longer, be more fuel efficient, and cheaper than ever before. These are just a few of the many benefits that breakthroughs in nanotechnology can provide. Imagine sending nanotech to the moon or other planets, setting up habitats without the risks to mankind?

In order to understand how nanotechnology works or is intended to work, it is first necessary to actually understand the term itself. Nanotechnology refers to assembling extremely small components into useful objects called nanostructures. These in turn will be assembled to make nanomachines. It is the size of these components that is perhaps their most remarkable aspect. They are so small it is virtually impossible to imagine. The prefix nano- means one billionth so a nanometre is one billionth of a metre. If you had a collection of objects that were one nanometre wide, you could fit 100,000 of those objects across a single human hair.

The basic building blocks of the universe are atoms which themselves are smaller than nanostructures but as yet science has not discovered how to manipulate and control atoms other than through chemical reactions. If you consider atoms to be akin to cement powder, then nanostructures are akin to concrete blocks. A concrete block on its own is not of much use but if you can manipulate concrete blocks into different sizes and shapes and combine them with other concrete blocks then you can make countless useful objects from a simple straight wall to a building like the Pentagon.

Scientists and engineers from many different disciplines are experimenting with nanotechnology and their belief is that they can create nanomachines which can be useful in many areas. The microchip industry is forever trying to condense the size of chips more and more and has had remarkable success in doing this. It is sobering to think that when IBM launched its first AT PC in the early 1980’s the hard disk that accompanied the machine was physically about half the size of a shoebox and had a storage capacity of 20 megabytes whereas just thirty years later disks not much bigger than a credit card can store thousands of times more data. But there is a limitation to how small chips can be made using standard technology. The hope is that nanotechnology will be the way forward in miniaturization.

On the medical front, nanotechnology is seen as a possible way to deliver extraordinary advances in disease treatment. The vision is of creating miniature components that can be introduced into the body via the bloodstream. The components would be programmable and assigned the task of perhaps seeking out cancer cells and destroying them without causing any damage to healthy cells. But the practical application currently in this area is a long way in the future.

Of more practical interest at present is using carbon atoms to build useful products. Carbon is the most versatile of all the elements in that it can form bonds with other elements in a unique fashion and can vary its own molecular structure. Carbon’s uniqueness amongst the elements is such that an entire branch of chemistry, organic chemistry, is devoted to carbon and its compounds. It is hoped that nanotechnology could produce carbon that will be as strong as steel but a fraction of its weight.

Nanotechnology is still in its infancy but already some experts are expressing concern about the potential risks of using nanotechnology.

Nanotechnology is concerned with manipulating matter almost at the atomic level. What that manipulation is designed to achieve depends very much on the area in which the technology is being applied. It may involve trying to make components that are microscopically small to be used in the manufacture of computer chips and integrated circuit boards. It may involve trying to give an object a property comparable to the same property of a rarer or more expensive item. Or it may involve trying to manipulate products in the food or medical industry.

Since nanotechnology works with material slightly above the atomic level, it is essentially concerned with creating new matter, or at least matter that is different in some way at the molecular level. What worries skeptics is that not enough research will be done into all of the properties of created objects and that may lead to harmful effects on the public.

To understand the safety concerns, it is necessary to have a little knowledge about how things work at the atomic level. Atoms are made up of molecules of elements which bind together to create a new product. Everyone knows that the chemical symbol for water is H2O which means that an atom of water consists of two atoms of the element hydrogen bound to one atom of the element oxygen. Water has its own unique properties which make it water and which are not shared by any other compound (although many will be very similar). We know that humans can ingest uncontaminated water without doing themselves any harm. But what if the manner in which the hydrogen and oxygen atoms bonded could be deliberately manipulated to form a slightly different type of bond? Would this alter the properties of the water possibly making it harmful to humans?

There are genuine reasons for this type of concern as can be demonstrated by examining carbon. Graphite (which is what makes pencils work) and diamond are both forms of pure carbon but bear no similarity to each other. Diamond is one of the hardest natural substances known, while graphite can be crumbled between the fingers. Graphite is a completely opaque dark color while diamond is shiny. As an electrical conductor diamond would be useless whereas graphite is a good conductor. What makes graphite and carbon so different from each other is down to the way the carbon atoms are joined to each other.

It is estimated that the current annual spend on nanotechnology is almost ten billion dollars yet virtually nothing is being spent on research into safety. Nanotechnology is set to influence every factor of human life in the future so safety is a vital issue especially in areas such as food, medicine and cosmetics where we will be ingesting this material. For example, experiments are in place to use nanotechnology to detect contaminants or spoilage in packed food items. When the food is ingested, so too will the detector.

The ways in which nanotechnology is being used are many and various and continue to grow at a remarkable pace. Nanotechnology is the science of producing sub-microscopic components which can be combined into useful products that can then be used in every imaginable way. Nanotechnology is found in manufacturing, plastics, aerospace, food processing, packaging, electronics, clothing and medicine to name just a few.

Nanotechnology is used in the production of batteries and energy storage systems. The nanotechnology materials provide high power output coupled with longer life while at the same time being lighter in weight and occupying less space than traditional products. And once the battery has reached the end of its useful life it is less of an environmental hazard because the nanotechnology parts are built to be chemically inert.

Ultra-thin membranes manufactured using nanomaterials are used in desalination plants. These have been demonstrated to produce up to 70% more water than traditional membranes and require up to 20% less energy to do so. The technology is used in creating a wide variety of filters which have many applications in environmental projects such as sewage treatment plants, water and gas purification.

Nanoparticles are used in coating solar panels. These particles can be created in the form of an ink and as such can be painted on to surfaces without needing to use a clean room, thus reducing manufacturing costs. They also have properties which makes them more efficient at generating electricity.

Nanotechnology is widely used in the automotive industry. One of the big problems facing manufacturers of cars, trucks, planes etc is reducing weight without compromising safety. Much progress has been made in developing lighter-weight metallic compounds and carbon fiber components. Nanotechnology provides even better weight to strength performance. Windscreen manufacturers also use nanotechnology. Nanoparticles integrated into the windscreen can become activated by the weather and actively dislodge dirt and insect debris from the windscreen. The particles can also influence how water spreads across the screen making the wipers more effective. Nanoparticles are also added to paints to make them scratch resistant.

Ever since the clothing industry existed its three big goals have been to produce clothing that is stain proof, water resistant and easy iron or crease proof. Several of these goals are being achieved by nanotechnology. Nanoparticles are sprayed onto the garments providing an effective shield against stains and water. And because the particles are actually rigid objects, they prevent garments from creasing.

So far the products we have looked at have functioned essentially as inert. But one of the most exciting areas of nanotechnology is in creating materials that will be designed to latch on to other materials. If this area proves successful we can expect to see nanoproducts being designed to mop up pollutants by attaching to specific chemicals or to mop up oil spills by attaching to the oil atoms. Similar technology could be used to create drugs which will attach to specific viruses and bacteria rendering them ineffectual.

Many people have never even heard of nanotechnology and of those who have, most of them are not really clear about what the technology involves. This has quite probably got something to do with the fact that nanotechnology development is taking place in almost every area of science, medicine, healthcare and manufacturing so quite a confused picture can emerge of what it actually means. What is almost certain is that every person in the developed world will have used or be using one or more products that incorporate nanotechnology.

In this article we are going to look at the uses and potential uses of nanotechnology in building materials. Because the technology is relatively new, only in modern buildings are we likely to find many of the nanotechnology components we will be referring to, but as the application of the technology becomes more widespread, repairs and renovations to older buildings will see them join the nanotechnology revolution.

Pilkington is one of the largest glass manufacturers in the world. It has launched a self-cleaning glass which will require less human intervention to maintain. The glass is developed using a nanoparticle coating which will use sunlight to cause a reaction with organic dirt it comes into contact with, preventing the dirt from becoming fixed to the glass. The dirt will be removed by rainfall or can be simply rinsed off. The glass is also designed to stop raindrops from splattering, instead turning rainfall into an evenly spread sheet of water which makes the cleaning even more effective. And it blocks uva and uvb radiation, beneficial to health and useful in managing internal temperature.

Nanotechnology is being deployed in the manufacture of exterior paint. Exterior paint has a really tough job having to cope with the worst the elements can throw at it. It has to able to withstand snow, rain, blazing sunshine and everything in between. Even the most durable paints will be overcome eventually, necessitating a repaint of the building. The application of nanotechnology in paint manufacturing has resulted in paints that are far more durable then traditional paints and that actually assist in insulation.

You will also find nanotechnology used in the manufacture of solar panels. While solar panels are clearly beneficial as an environmental protector and energy cost saver, the purchase cost of the panels is sufficiently high enough to deter the majority. Many panel manufacturers believe that the cost savings achieved by using nanotechnology will bring the price of panels down enough to make them affordable to a lot more people.

Most new buildings will have environmental control panels for heating, air and water filtration and so on. Most modern panels used will incorporate nanotechnology making them more sophisticated yet cheaper control devices. And for houses being built in remote areas and not connecting to municipal sewage disposal systems, nanotechnology offers greatly improved filtration and breakdown systems.

There are many more products in the pipeline which will revolutionize the way modern houses are designed and built. And the nanotechnology revolution will affect not only the building materials, but also in the future everything inside the house from furniture to electronics to utensils.

When you look at history, you come across inspiring names. You come across people that have changed the world with their speeches, actions and inventions. You come across people you want to be like but you envy at the same time. People all over the world like knowing who is responsible for what in a specific area. Technology is not left out. People like knowing who is behind the computer, who is behind the vehicle, who is behind the cure for small pox and so on. Technology has improved so much that we can now manipulate atoms and molecules the way we want. We can manipulate the universe. This form of technology is nanotechnology. I know what you are going to ask. Who invented nanotechnology?

When you stroll through history, you will realize that there is no single name behind this kind of technology. In short, there is no single name that we can point out as the inventor of nanotechnology. However, the word itself was coined by Norio Taniguchi in 1974. He was a professor. The idea on the other hand, was first thought of by Richard Feynman in the year 1959. He first talked of the idea while giving a lecture at the American Physical Meeting Society. He discussed a process through which molecules and atoms could be controlled using instruments that were specially designed. Obviously at this time the word nanotechnology had not yet emerged. However, his lecture was an accurate description of the science.

Interesting facts about nanotechnology came about with Taniguchi’s work. He further described the procedure as the consolidation or separation of atoms or molecules in his 1974 paper. The man who completely popularized nanotechnology was Dr. K Eric Drexler in his book “Engines of Creation” which came out in 1986. It was the first book in history to give a detailed concept on the subject.

The creation of the scanning tunneling microscope and the discovery of fullerenes further propelled nanotechnology’s popularity in the mid 80s. Its evolution was catapulted by the emergence of semiconductor nanocrystals which consequentially led to an increase of metal oxide nanoparticles. Quantum dots also grew from this. These quantum dots help a lot when it comes to applying nanotechnology in medicine.

By 1988, courses on the subject were being offered in universities. Since knowledge was being distributed, the atomic force microscope came into existence in 1991 and further down the same decade, there was increased use and manipulation of carbon nanotubes. Of course when you talk about a new phenomenon, there has to be benefits and risks. One of its major benefits is that it can create pure and clean water. It can also help in producing cheap energy and efficient drugs and medicines. The major risk is that people still do not know how much it can affect the environment and human health.

Every time you ask who invented nanotechnology, remember Richard Feynman, Professor Taniguchi and the inventors of the scanning tunneling microscope and fullerenes. These are the names that you should envy. These are the names that you should forever store in your memory.


Atom-thick sheets unlock future technologies A new way of splitting layered materials to give atom thin "nanosheets" has been discovered. This has led to a range of novel two-dimensional nanomaterials with chemical and electronic properties that have the potential to enable new electronic and energy storage technologies. The collaborative* international research led by the Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN), Trinity College Dublin, Ireland, and the University of Oxford has been published in this week's Science. The scientists have invented a versatile method for creating these atom thin nanosheets from a range of materials using common solvents and ultrasound, utilising devices similar to those used to clean jewellery. The new method is simple, fast, and inexpensive, and could be scaled up to work on an industrial scale. "Of the many possible applications of these new nanosheets, perhaps the most important are as thermoelectric materials. These materials, when fabricated into devices, can generate electricity from waste heat. For example, in gas-fired power plants approximately 50% of energy produced is lost as waste heat while for coal and oil plants the figure is up to 70%. However, the development of efficient thermoelectric devices would allow some of this waste heat to be recycled cheaply and easily, something that has been beyond us, up until now," explained Professor Jonathan Coleman, Principal Investigator at CRANN and the School of Physics, Trinity College Dublin who led the research along with Dr Valeria Nicolosi in the Department of Materials at the University of Oxford.

This research can be compared to the work regarding the two-dimensional material graphene, which won the Nobel Prize in 2010. Graphene has generated significant interest because when separated into individual flakes, it has exceptional electronic and mechanical properties that are very different to those of its parent crystal, graphite. However, graphite is just one of hundreds of layered materials, some of which may enable powerful new technologies.
Coleman's work will open up over 150 similarly exotic layered materials – such as Boron Nitride, Molybdenum disulfide, and Bismuth telluride – that have the potential to be metallic, semiconducting or insulating, depending on their chemical composition and how their atoms are arranged. This new family of materials opens a whole range of new "super" materials. For decades researchers have tried to create nanosheets from layered materials in order to unlock their unusual electronic and thermoelectric properties. However, previous methods were time consuming, laborious or of very low yield and so unsuited to most applications. "Our new method offers low-costs, a very high yield and a very large throughput: within a couple of hours, and with just 1 mg of material, billions and billions of one-atom-thick nanosheets can be made at the same time from a wide variety of exotic layered materials," explained Dr Nicolosi, from the University of Oxford. These new materials are also suited for use in next generation batteries – "supercapacitors" – which can deliver energy thousands of times faster than standard batteries, enabling new applications such as electric cars. Many of these new atomic layered materials are very strong and can be added to plastics to produce super-strong composites. These will be useful in a range of industries from simple structural plastics to aeronautics.

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